DNA structure and recognition

DNA structure and recognition by Stephen Neidle Download PDF EPUB FB2

Buy DNA damage; effects on DNA structure and protein recognition. by Susan S. Wallace, Bennett Van Houten and Yoke Wah Kow. (Annals of the New York Academy of Sciences, Vol. ) on FREE SHIPPING on qualified orders. ISBN: X OCLC Number: Description: ix, pages: illustrations (some color) ; 23 cm.

Contents: Methods for studying DNA structure --X-ray diffraction methods for structural analysis --NMR methods for studying DNA structure and dynamics --Molecular modeling and simulation of DNA --Chemical and enzymatic probes of structure --Sources of structural data.

DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications.

The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations.

To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins.

DNA replication occurs when the DNA strands “unzip,” and the original strands of DNA serve as a template for new nucleotides to join and form a new strand. Summary During DNA replication, the DNA helix unwinds and the two single strands of DNA then each. Many DNA-binding proteins possessing disparate functions have been shown to bend their DNA recognition sites (28, 44, 45).

A distinction can be made, however, between those proteins whose primary, if not sole, function is to bend DNA, and those proteins that happen to bend DNA in the process of carrying out their distinct primary by: It is a popular science book written by well known experts in the field of DNA structure.

It is concentrated on fine features of the DNA molecular structure, which play very important role in DNA functioning. Such issues as DNA bending and DNA winding in the nucleosome particles is covered in significant details.

Many HMG-domain proteins recognize altered DNA structures such as four-way junctions and cisplatin-modified DNA5, but until now the molecular basis for this recognition Cited by: We also hypothesize that for each of the recognition sequences, an ordered DNA barrel structure forms only on one particular (n,m) tube, resulting in their purification by IEX.

Figure 2: DNA Cited by: An example of inhibitory RNA aptamers binding the NF-kappaB transcription factor by molecular mimicry of the normal DNA target from the Nucleic Acid Structure and Recognition Lab led by Jim Maher, Ph.D., at Mayo Clinic.

The research laboratory of Jim Maher, Ph.D., studies the nucleic acids DNA and. A genetics book, by the one of the co-discoverers of the double helix structure of DNA. There's a few chapters about the science, about the history of genetics and then a variety of topics, genetically modified foods and the controversy, DNA evidence in solving crimes, genetic diseases, ancient racial ancestry, ethical questions, bio-tech politics/5().

In practice, DNA recognition by proteins effectively spans a continuum from completely digital to completely analogue with many proteins utilizing both modes.

For both modes of recognition, the DNA double helix differs from, and is arguably more effective than, the RNA double by: Transcription factors are classified in families according to the structure of their DNA-binding domain.

eukaryotic transcription factors as an introduction to the specific chapters dealing with the structure and function of plant transcription factors in this book. including recognition of a narrowed minor groove of DNA.

DNA STRUCTURE DNA Is Composed of Polynucleotide Chains The most important feature of DNA is that it is usually composed of two polynucleotide chainstwisted around each other in the form of a double helix (Figure ). The upper part of the figure (a) presents the structure of the double helix shown in a schematic form.

Note that ifFile Size: 1MB. Understanding DNA recognition by TAL effectors may facilitate rational design of DNA-binding proteins with biotechnological applications.

TAL (transcription activator–like) effectors (TALEs) are major virulence factors secreted by bacteria of the genus Xanthomonas that cause diseases in plants such as rice and cotton (1 – 4).Cited by: Direct and indirect readout of DNA-recognition.

sites by proteins is a major determinant of binding. selectivity. In direct readout, the individual bases in a DNA structure and function A. DNA was first recognized and identified by the Swiss biologist, Johannes Friedrich Miescher in during his research on white blood cells.

The double helix structure of a DNA molecule was later discovered through the experimental data by James Watson and Francis Crick. The DNA double helix, one of the most influential discoveries in the history of science, revealed how information is stored and replicated in living organisms.

Francis Crick and Jim Watson did not exaggerate when they proclaimed that they had found "the secret of life" at the Eagle Pub in The double helix has since become the foundation of modern biology and its most iconic image.

Rosalind Franklin is known for her role (largely unacknowledged during her lifetime) in discovering the helical structure of DNA, a discovery credited to Watson, Crick, and Wilkins—received a Nobel Prize for physiology and medicine in Franklin might have been included in that prize, had she lived.

Watson and Crick structure of DNA was published): Full sequence published and researchers determined that within this sequence there was somewhere betw genes. We now believe there are closer to 25, genes. ― Steve Jones in, James D. Watson's The Double Helix I gave it three stars last night (DNA night, thanks Riku), but that just didn't seem right.

The structure wasn't stable, and I felt it probably deserved four stars (one for A, one for T, one for G, one for C; also one for Watson, one for Crick, one for Wilkins, and yes one for Franklin)/5().Other scientists were also actively exploring this field during the midth century.

InAmerican scientist Linus Pauling (–) was the world’s leading structural chemist and odds-on favorite to solve the structure of DNA. Pauling had earlier discovered the structure of protein α helices, using X-ray diffraction, and, based upon X-ray diffraction images of DNA made in his.Speculation on the biological roles of left-handed Z-DNA / Alexander Rich --Crystal and solution structures of d(CGC[e6G]AATTCGCG)-drug complexes reveal conformational polymorphism of O6-ethyl-guanine: cytosine base pair / M.

Spiram [and others] --DNA lesions: a thermodynamic perspective / G. Eric Plum, Kenneth J. Breslauer --Molecular.